The current issue of the journal Cell has a very interesting paper on the concept of personalomics. Personalised medicine has one of the buzz words in medicine, but a concept that has promised so much but delivered little. That is until now. With significant decrease in cost of gene sequencing we will be hearing about this more and more in the coming few years. in this study the scientists analyzed the genomic, transcriptomic, proteomic, metabolomic, and autoantibody profiles from a single individual over a 14 month period in relation to type 2 diabetes. This was presented as an Integrative personal omics profile (iPOP)- (why does “i” keep propping up wherever a cool concept is discussed). Nevertheless this is fascinating concept and hopefully it is filtered down to clinical practice in the next few years.